FAM72A promotes mutagenic repair during antibody maturation

ABSTRACT: Genome-wide CRISPR screen in murine CH12F3-2 cell line to identify novel factors involved in antibody class switch recombination. FAM72A, a protein with no ascribed function, was identified in this screen as a major determinant during mutagenic uracil repair by antagonizing base excision repair protein UNG2.

ORGANISM(S): Mus musculus

PROVIDER: GSE183706 | GEO | 2021/09/11

REPOSITORIES: GEO