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Drosophila photoreceptor chromatin accessibility landscape upon disruption of Clock activity [ClkATACseq]

ABSTRACT: We report the chromatin accessibility landscape of Drosophila photoreceptor neurons obtained using a tissue-specific approach at different time points after eclosion upon expression of a Clock dominant negative mutant

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE183746 | GEO | 2021/12/31

REPOSITORIES: GEO

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Drosophila photoreceptor transcriptome landscape upon disruption of Clock activity [Rh1-ClkDN_RNA]

Project description:We report the transcriptome landscape of Drosophila photoreceptor neurons obtained using a tissue-specific approach at different time points after eclosion upon expression of a Clock dominant negative mutant

2021-12-31 | GSE184121 | GEO

Drosophila photoreceptor chromatin accessibility landscape upon disruption of Clock activity [ClkATACseq]

Project description:Drosophila photoreceptor chromatin accessibility landscape upon disruption of Clock activity [ClkATACseq]

| PRJNA761801 | ENA

Drosophila photoreceptor transcriptome landscape upon disruption of Clock activity [Rh1-ClkDN_RNA]

Project description:Drosophila photoreceptor transcriptome landscape upon disruption of Clock activity [Rh1-ClkDN_RNA]

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Drosophila photoreceptor nuclear RNA-seq timecourse

Project description:We report the nuclear transcriptome of Drosophila photoreceptor neurons obtained using a tissue-specific approach at different time points after eclosion

2021-12-31 | GSE174515 | GEO

Drosophila photoreceptor nuclear RNA-seq timecourse [AgingATACseq]

Project description:We report the chromatin accessibility landscape of Drosophila photoreceptor neurons obtained using a tissue-specific approach at different time points after eclosion

2021-12-31 | GSE184069 | GEO

Core Circadian Clock Genes Per1 and Per2 regulate the Rhythm in Photoreceptor Outer Segment Phagocytosis [Photoreceptor]

Project description:Core Circadian Clock Genes Per1 and Per2 regulate the Rhythm in Photoreceptor Outer Segment Phagocytosis [Photoreceptor]

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Core Circadian Clock Genes Per1 and Per2 regulate the Rhythm in Photoreceptor Outer Segment Phagocytosis [Photoreceptor]

Project description:Retinal photoreceptors undergo daily renewal of their distal outer segments, a process indispensable for maintaining retinal health. Photoreceptor Outer Segment (POS) phagocytosis occurs as a daily peak, roughly about one hour after light onset. However, the underlying cellular and molecular mechanisms which initiate this process are still unknown. Here we show that, under constant darkness, mice deficient for core circadian clock genes (Per1 and Per2), lack a daily peak in POS phagocytosis. By qPCR analysis we found that core clock genes were rhythmic over 24h in both WT and Per1, Per2 double mutant whole retinas. More precise transcriptomics analysis of laser capture microdissected WT photoreceptors revealed no differentially expressed genes between time-points preceding and during the peak of POS phagocytosis. By contrast, we found that microdissected WT retinal pigment epithelium (RPE) had a number of genes that were differentially expressed at the peak phagocytic time-point compared to adjacent ones. We also found a number of differentially expressed genes in Per1, Per2 double mutant RPE compared to WT ones at the peak phagocytic time-point. Finally, based on STRING analysis we found a group of interacting genes which potentially drive POS phagocytosis in the RPE. This potential pathway consists of genes such as: Pacsin1, Syp, Camk2b and Camk2d among others. Our findings indicate that Per1 and Per2 are necessary clock components for driving POS phagocytosis and suggest that this process is transcriptionally driven by the RPE.

2021-06-01 | GSE172437 | GEO

Genome-wide R-loop distribution in Drosophila photoreceptor neurons throughout aging

Project description:We report the application of R-loop mapping in a cell-type specific context using photoreceptor neurons at different ages, as measured by days post eclosion (Day 10, Day 30 and Day 50). To validate our approach, we also performed R-loop mapping in 10 day old nuclei that were treated with RNAse H1 for 3 hours prior to application of MapR.

2021-12-31 | GSE174488 | GEO

GIGANTEA recruits deubiquitylases, UBP12 and UBP13, to regulate accumulation of the ZTL photoreceptor complex

Project description:ZEILUPE (ZTL), a blue light photoreceptor with E3 ubiquitin ligase activity, communicates end-of-day light conditions to the circadian clock. To function properly, ZTL protein must accumulate but not destablilize target clock transcription factors before dusk, while in the dark ZTL mediates degradation of target proteins. It is not clear how ZTL can accumulate to high levels in the ligh while its targets remain stable. Two deubiquitylating enzymes, UBIQUITIN-SPECIFIC PROTEASE 12 and UBIQUITIN-SPECIFIC PROTEASE 13 (UBP12 and UBP13), which regulate colock period and protein ubiquitylation in a manner opposite to ZTL, were shown to associate with the ZTL protein complex. Here we demonstrate that the ZTL light-dependent interacting partner GIGANTEA (GI), recruites UBP12 and UBP13 to the ZTL photoreceptor complex.

2019-08-22 | PXD014636 | Pride

Core Circadian Clock Genes Per1 and Per2 regulate the Rhythm in Photoreceptor Outer Segment Phagocytosis [RPE]

2021-06-01 | GSE172438 | GEO

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