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Gene expression profiling of human DLBCL tumor samples (SGN-40 trial)

ABSTRACT: We profiled human DLBCL patient samples to discover predictive biomarkers Keywords: DLBCL SGN-40 FFPE

ORGANISM(S): Homo sapiens

PROVIDER: GSE18376 | GEO | 2011/03/16

SECONDARY ACCESSION(S): PRJNA118145

REPOSITORIES: GEO

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Gene expression profiling of human DLBCL tumor samples (SGN-40 trial)

Project description:We profiled human DLBCL patient samples to discover predictive biomarkers Keywords: DLBCL SGN-40 FFPE RNA profiles of human FFPE samples (DLBCL)

2011-03-16 | E-GEOD-18376 | biostudies-arrayexpress

Gene expression profiling of human DLBCL tumor samples (FF and FFPE pairs)

Project description:We profiled human DLBCL tumor samples (FF and FFPE matched pairs) to identify the transcripts which are less prone to degradation in FFPE Keywords: DLBCL FF FFPE

2011-03-16 | GSE18377 | GEO

Gene expression profiling of human DLBCL tumor samples (FF and FFPE pairs)

Project description:We profiled human DLBCL tumor samples (FF and FFPE matched pairs) to identify the transcripts which are less prone to degradation in FFPE Keywords: DLBCL FF FFPE RNA profiles of human FF and FFPE samples (DLBCL)

2011-03-16 | E-GEOD-18377 | biostudies-arrayexpress

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Project description:Rapid proteotyping of 41 FFPE DLBCL tumor tissues with 2-3 biological replicates using pressure-cycling technology (PCT) and SWATH mass spectrometry.

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Homo sapiens

Project description:Gene expression profiling of human DLBCL tumor samples (SGN-40 trial)

| PRJNA118145 | ENA

Integrated Copy Number Analysis of Epstein Barr Virus (EBV)-Positive Diffuse Large B-Cell Lymphoma (DLBCL)

Project description:Copy number analysis was performed on EBV+ DLBCL samples compared with EBV- DLBCL. We analyzed the genomic DNA from 18 cases of EBV+ DLBCL, 21 cases of EBV- DLBCL, and 13 cases of nonneoplastic tonsillar tissues using OncoScan FFPE Express 2.0 (MIP). No technical replication were done.

2014-02-01 | E-MTAB-1971 | biostudies-arrayexpress

GOYA DLBCL clinical trial - RNASeq dataset

Project description:GOYA DLBCL clinical trial - RNASeq dataset

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Expression data from 40 lymphomas (Hodgkin, B cell, T cell)

Project description:We produced and analyzed the transcriptomic profiles of 40 lymphoma patients. We used microarrays to compare the global gene expression profile between the different subtypes. These samples were analyzed with a tool predictive of immune escape mechanisms previously developped, IEGS33. Depending on lymphoma subtype, different immune escape signatures can be observed. Therapeutic based on PD-1/PD-L1 blockade shows promising results in Hodgkin lymphoma (HL) and in some diffuse large B-cell lymphoma (DLBCL) patients but biomarkers predicting therapeutic response are still lacking. To gain understanding on the overall immune-escape (IE) mechanism, we recently developed a tool to score the transcriptional IE hallmarks in lymphoma samples and identified four stages of cancer immune-editing in DLBCL that correlated with overall survival. Through this method, we described here the IE profiles in HL and DLBCL from a meta-analysis of large series of microarrays. We observed that HL clustered together at the late equilibrium-early escape stage of cancer immune-editing with significant enrichment of genes involved in IE and T-cell activation as compared to DLBCL. Deconvolution of transcriptomes and immunohistochimistry showed that HL had higher CD3+ and CD4+ T-cells than all DLBCL and shared high abundance of CD8+ T-cells with DLBCL ABC and low infiltrates of CD68+CD163+ macrophages with DLBCL GC. HL and DLBCL shared the same cellular distribution of PD-1 and TIM3 staining but HL exhibited a higher expression of PD-L1 in tumor cells as well as LAG3 overexpression in ME as compared to DLBCL. Finally, our bioinformatic tools based on IEGS33 and T cell activation scores as global approach of immune escape mechanisms help to investigate in details the ME of HL. This method may be useful tool to identify HL as well as DLBCL patients who better benefit from immunotherapy strategies.

2018-12-26 | GSE120124 | GEO

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Project description:Gene expression profiling was performed for 28 DLBCL primary clinical samples and assignment of activated B-cell-like(ABC)/germinal center B-cell-like (GCB) DLBCL classes, B-cell-associated gene signature (BAGS), and a probability of response to doxorubicin was performed for each sample.

2016-10-05 | GSE74266 | GEO

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Project description:Gene expression profiling was carried out for RNA extracted from Formalin-fixed, paraffin embedded (FFPE) biopsies for 1311 patients with diffuse large b-cell lymphoma (DLBCL) using the Illumina DASL platform.

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