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Physically interacting beta-delta pairs in the regenerating pancreas revealed by single-cell sequencing

ABSTRACT: We report that delta cells are Sox9 descendants that expand at the periphery of the regenerating islets following partial pancreatectomy. We further characterize regeneration-driven heterogeneity of beta cells at a single-cell resolution, demonstrating sub-populations of ER-stressed, proliferating and highly-functioning beta-cells. We further systematically map sub populations of beta-cells that are paired with other endocrine cell types. Our analysis suggests that the particular cluster of beta-cells that pair with delta-cells benefits from stress protection, implying that the interaction between beta and delta-cells safeguards against regeneration-associated challenges.

ORGANISM(S): Mus musculus

PROVIDER: GSE183788 | GEO | 2021/09/10

REPOSITORIES: GEO

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