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Global gene expression of canine bladder K9TCC cells and cancer stem cells after COX-2 inhibition

ABSTRACT: Cancer stem cells (CSCs) are fundamental to bladder cancer progression and the cyclooxygenase-2 (COX-2) pathway has a pro-tumorigenic role in CSC function. Naturally occurring bladder cancer in dogs has the potential to be a natural model of the human disease. Here, we used canine specific microarrays to determine changes in global gene expression of canine bladder cancer cells (the K9TCC cell line) and bladder cancer stem cells isolated from the K9TCC cell line after treatment with the selective COX-2 inhibitor mavacoxib or a COX-2 siRNA.

ORGANISM(S): Canis lupus familiaris Canis lupus

PROVIDER: GSE183793 | GEO | 2022/07/20

REPOSITORIES: GEO

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