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Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans

ABSTRACT: Single cell analysis of older, hyposmic adult and normosmic adult olfactory epithelium yields evidence for inflammation-associated changes in the OE stem cells of presbyosmic patients

ORGANISM(S): Homo sapiens

PROVIDER: GSE184117 | GEO | 2022/01/21

REPOSITORIES: GEO

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Project description:Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans

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Characterizing the expression of human olfactory receptor genes

Project description:We aim, among other things, to characterize olfactory receptor (OR) genes wich are differentially expressed between olfactory epithelium (OE) and other organ tissues, in humans. Six OE samples and ten non-OE samples, including two samples of the following tissues: liver, kidney, lung, testis, and heart.

2010-06-11 | E-GEOD-5969 | biostudies-arrayexpress

RNA profiles of rat olfactory epithelia : individual and age related variations (age experiment)

Project description:Background: Mammalian genomes contain a large number (~1000) of olfactory receptor (OR) genes, many of which (20 to 50 %) are pseudogenes. OR gene transcription is not restricted to the olfactory epithelium, but is found in numerous tissues. Using microarray hybridization and RTqPCR, we analyzed the mRNA profiles of the olfactory epithelium of male and female Brown Norway rats of different origins and ages (newborn, adult and old). Results: (1) We observed very little difference between males and females and between rats from two different suppliers. (2) Different OR genes were expressed at varying levels, rather than uniformly across the four endoturbinates. (3) A large proportion of the gene transcripts (2/3 of all probes) were detected in all three age groups. Adult and older rats expressed similar numbers of OR genes, both expressing more OR genes than newborns. (4) Comparisons of whole transcriptomes or transcription profiles of expressed OR genes only showed a clear clustering of the samples as a function of age. (5) Most OR genes were expressed at lower levels at birth than in older animals, but a small number of OR genes were expressed specifically or were overexpressed in newborns. Conclusions: Not all OR genes are expressed at a detectable level. Pups expressed fewer OR genes than adult rats, and generally at a lower level; however, a small subset of OR genes were more strongly expressed in these newborn rats. The reasons for these differences are not understood. However, the specific expression of some OR genes in newborn olfactory epithelia may be related to the blindness and deafness of pups at birth, when these pups are heavily reliant on olfaction and their mother.

2009-11-01 | GSE15953 | GEO

Single-cell analysis of olfactory neurogenesis and differentiation in adult humans

Project description:We performed single-cell RNAseq of human olfactory and respiratory epithelium and found evidence of olfactory neurogenesis and differentiation in adult humans.

2019-12-18 | GSE139522 | GEO

RNA profiles of rat olfactory epithelia : individual and age related variations (gender/supplier experiment)

2009-11-01 | GSE15952 | GEO

Characterizing the expression of Pan troglodytes olfactory receptor genes

Project description:We aim, among other things, to characterize olfactory receptor (OR) genes wich are differentially expressed between olfactory epithelium (OE) and other organ tissues, in chimpanzees (Pan troglodytes), and to make comparisons with human data from a previous series using the same platform. Keywords: Comparative Four OE samples and eight non-OE samples, including two samples of the following tissues: heart, liver, lung, and testis.

2008-10-01 | E-GEOD-11156 | biostudies-arrayexpress

Chip-chip from mouse olfactory epithelium (OE) and liver with antibodies against H3K9me3 and H4K20me3

Project description:The Olfactory Receptor (OR) genes are specifically expressed in the MOE in a monogenic and monoallelic fashion. Only 1 out of 2800 alleles is expressed in each olfactory sensory neuron in mice. ChIP-chip from mouse olfactory epithelium (OE) and liver for H3K9me3 and H4K20me3 revealed that the ORs are highly enriched for these modifications in OE but not in liver. 24 samples were analyzed (20 from OE and 4 from liver) with matching inputs as controls. For the OE samples, there were 2-3 replicates for each array.

2011-05-03 | E-GEOD-24420 | biostudies-arrayexpress

Deep sequencing of the murine olfactory receptor neuron transcriptome

Project description:The recent development of next-generation sequencing (NGS) techniques encouraged us to assess the transcriptome of the murine OE. We analyzed RNA from OEs of female and male adult mice and from fluorescence-activated cell sorting (FACS)-sorted olfactory receptor neurons (ORNs) obtained from transgenic OMP-GFP mice

2015-01-21 | GSE53793 | GEO

Characterizing the expression of human olfactory receptor genes

2007-02-01 | GSE5969 | GEO

Transcription profiling of mouse olfactory epithelium to determine the identity of genes regulated at 3 d post-olfactory bulbectomy in the olfactory mucosa of carrier-injected Ccl3-/- mice compared with carrier-injected C57BL/6 mice

Project description:The aim was to determine the identity of genes regulated at 3 d post-olfactory bulbectomy in the olfactory mucosa of carrier-injected Ccl3-/- mice compared with carrier-injected C57BL/6 mice. Total RNA from the OE was hybridized to Affymetrix microarrays. A number of chemokine-, cytokine-, and growth factor-related genes were significantly regulated in the Ccl3-/- mice, and were restored in CCL3 protein-injected Ccl3-/- mice. The results illustrated that CCL3 played a key role in recruitment of macrophages to the OE and provided insight into the genomic regulation involved in OE remodeling.

2007-10-13 | E-GEOD-1680 | biostudies-arrayexpress

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