Dataset Information


Therapeutic radiation exposure of the abdomen during childhood induces chronic adipose tissue dysfunction

ABSTRACT: Childhood cancer survivors who received abdominal radiotherapy (RT) or total body irradiation (TBI) are at increased risk for cardiometabolic disease, but the underlying mechanisms are unknown. We hypothesize that RT-induced adipose tissue dysfunction contributes to the development of cardiometabolic disease in the expanding population of childhood cancer survivors. We performed bulk RNA-sequencing of abdominal subcutaneous adipose tissue from adult childhood cancer survivors previously exposed to TBI, abdominal RT, or chemotherapy alone, alongside a group of healthy controls. We find that irradiated adipose tissue is characterized by a gene expression signature indicative of a complex macrophage expansion, which is also associated with dysregulated adipokine secretion. The full cohort is 30 subjects; however, 3 participants (2 in CHM group, 1 in CTL group) declined to share their sequencing data in a public database. Overall design: Observational cohort with 4 groups: CTL (healthy controls); CHM (chemotherapy only); ABM (chemo+abdominal radiation); TBI (chemo+total body irradiation).

INSTRUMENT(S): Illumina NovaSeq 6000 (Homo sapiens)

ORGANISM(S): Homo sapiens  

SUBMITTER: Paul Cohen  

PROVIDER: GSE184148 | GEO | 2021-09-17


Dataset's files

Action DRS
GSE184148_counts.txt.gz Txt
Items per page:
1 - 1 of 1

Similar Datasets

2020-01-01 | S-EPMC7473918 | BioStudies
2011-01-01 | S-EPMC3302129 | BioStudies
2014-01-01 | S-EPMC4228784 | BioStudies
2017-01-01 | S-EPMC5551414 | BioStudies
2018-01-01 | S-EPMC5964004 | BioStudies
2017-01-01 | S-EPMC5409032 | BioStudies
2018-01-01 | S-EPMC6219017 | BioStudies
2020-01-01 | S-EPMC7225668 | BioStudies
2012-01-01 | S-EPMC3374397 | BioStudies
2016-01-01 | S-EPMC5426536 | BioStudies