Transcriptomics,Genomics

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Therapeutic radiation exposure of the abdomen during childhood induces chronic adipose tissue dysfunction


ABSTRACT: Childhood cancer survivors who received abdominal radiotherapy (RT) or total body irradiation (TBI) are at increased risk for cardiometabolic disease, but the underlying mechanisms are unknown. We hypothesize that RT-induced adipose tissue dysfunction contributes to the development of cardiometabolic disease in the expanding population of childhood cancer survivors. We performed bulk RNA-sequencing of abdominal subcutaneous adipose tissue from adult childhood cancer survivors previously exposed to TBI, abdominal RT, or chemotherapy alone, alongside a group of healthy controls. We find that irradiated adipose tissue is characterized by a gene expression signature indicative of a complex macrophage expansion, which is also associated with dysregulated adipokine secretion. The full cohort is 30 subjects; however, 3 participants (2 in CHM group, 1 in CTL group) declined to share their sequencing data in a public database. Overall design: Observational cohort with 4 groups: CTL (healthy controls); CHM (chemotherapy only); ABM (chemo+abdominal radiation); TBI (chemo+total body irradiation).

INSTRUMENT(S): Illumina NovaSeq 6000 (Homo sapiens)

ORGANISM(S): Homo sapiens  

SUBMITTER: Paul Cohen  

PROVIDER: GSE184148 | GEO | 2021-09-17

REPOSITORIES: GEO

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