Project description:Transcriptional profiles of cultured human breast and prostate cancer cell lines treated with small molecules: 6 cancer cell lines are treated with 6 small molecules, as a part of the LINCS Trans-Center Project. The expression level for 978 representative genes is measured.
Project description:Transcriptional profiles of U2 OS cell line treated with ~21 thousands of compounds from diversity-oriented-synthesis (DOS) library.
Project description:Each of 70 cell samples either at the control condition or treated with FDA-approved cancer drugs is sequenced by the single-ended random-primed mRNA-sequencing method with a read length of 100 base pairs, and a total of 70 raw sequence data files in the FASTQ format are generated. These sequence data files are then analyzed by a high-performance computational pipeline and ranked lists of gene signatures and biological processes related to drug-induced cardiotoxicity are generated for each drug. The raw sequence datasets and the analysis results have been carefully controlled for data quality, and they are made publicly available at the Gene Expression Omnibus (GEO) database repository of NIH. As such, this broad drug-stimulated transcriptomi dataset is valuable for the prediction of drug toxicities and their mitigations.
