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SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression [BSA_0275_SMNDC1]

ABSTRACT: We have found that loss of SMNDC1 (Survival Motor Neuron Domain Containing 1), a component of the spliceosome complex, in both murine alpha cells and human islets is capable of inducing an overall increase in beta cell markers and activating insulin transcription.

ORGANISM(S): Mus musculus

PROVIDER: GSE184214 | GEO | 2022/07/01

REPOSITORIES: GEO

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SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression [BSA_0337_Smndc1_KD]

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