Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Loss of skin and mucosal CXCR3+ resident memory T cells causes irreversible tissue-confined immunodeficiency in HIV

ABSTRACT: Single cell RNA-seq , VDJ DNA sequencing and Bulk RNA-seq sequencing of human skin and blood CD45+ cells from HIV+ patients and healthy controls

ORGANISM(S): Homo sapiens

PROVIDER: GSE184320 | GEO | 2021/11/22

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Loss of skin and mucosal CXCR3+ resident memory T cells causes irreversible tissue-confined immunodeficiency in HIV

Project description:Loss of skin and mucosal CXCR3+ resident memory T cells causes irreversible tissue-confined immunodeficiency in HIV

| PRJNA763993 | ENA

CXCR3 Provides a Competitive Advantage for Retention of <i>Mycobacterium tuberculosis</i>-Specific Tissue-Resident Memory T Cells Following a Mucosal Tuberculosis Vaccine.

Project description: Not available

| S-EPMC10611282 | biostudies-literature

ScRNA/TCR-seq of T cells from EMT6 tumors treated with aTGFb/aPD-L1

Project description:We performed 10x single cell RNA and VDJ sequencing on sorted T cells (7AAD- Calcein blue+ CD45+ THY1.1- TCRb+) in an orthotopic EMT6 tumor model 7 days after treatment initiation in four experimental groups: 1) Control 2) aPD-L1 3) aTGFb 4) aPD-L1 and aTGFb.

2023-06-30 | E-MTAB-13073 | biostudies-arrayexpress

Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor.

Project description: Not available

| S-EPMC1866035 | biostudies-literature

A de novo mutation in /ITPR3/ causes combined immunodeficiency

Project description:This study reports two unrelated patients with a combined immunodeficiency. Whole-exome sequencing of both patients, their healthy parents and siblings identified in both families a /de novo/ missense variant in /ITPR3/ (NM_002224.3:c.7570C>T, p.Arg2524Cys). While the mRNA level in patients remained the same as in healthy siblings and controls, the level of protein expression was diminished. It was also shown that the ITPR3 heterozygous p.Arg2524Cys mutation impairs calcium flux function in dermal fibroblast of one patient and in a knock-in Jurkat T cell line.

2024-06-18 | PXD038284 | Pride

Vaccine-induced tissue resident memory T cells and antibodies synergize to prevent mucosal HIV infection [CITE-seq]

Project description:This study measures single cell RNA and protein expression in Gag stimulated and non-stimulated vaginal tissue from four SIV-protected rhesus macaques.

2020-03-05 | GSE138156 | GEO

Inflammatory Skin Disease Causes Anxiety Symptoms Leading to an Irreversible Course.

Project description: Not available

| S-EPMC10058663 | biostudies-literature

A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency.

Project description: Not available

| S-EPMC12486176 | biostudies-literature

A de novo mutation in ITPR3 causes severe combined immunodeficiency

Project description:This study reports two unrelated patients with a combined immunodeficiency. Whole-exome sequencing of both patients, their healthy parents and siblings identified a single de novo missense variant in ITPR3 (NM_002224.3:c.7570C>T, p.Arg2524Cys) in both index cases. While the mRNA level in patients remained the same as in healthy siblings and controls, the level of protein expression was diminished. It was also shown that the ITPR3 heterozygous p.Arg2524Cys mutation impairs calcium flux function in dermal fibroblast of one patient and in a knock-in Jurkat T cell line. Two additional patients with related phenotypes and the same mutation were further identified and described in the study. The present dataset corresponds to the RNAseq performed on PBMC of patient 2 of the study and healthy controls.

2023-01-02 | E-MTAB-12432 | biostudies-arrayexpress

RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics.

Project description: Not available

| S-EPMC6400263 | biostudies-literature