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Reprogramming of ovarian aging epigenome by resveratrol [methylation]

ABSTRACT: Depletion of oocytes and follicles and reduced oocyte quality contribute to age-associated ovarian senescence and infertility. Telomere shortening and altered methylation make two major contributions to general aging. Resveratrol acts as anti-oxidant and Sirt1 activator to alleviate aging including reproductive aging. It remains elusive whether resveratrol can reprogram the aging epigenome. We sought to examine aging ovarian epigenome and the potential effects of resveratrol by combined analysis of telomere length, transcriptome and methylome mainly in oocytes and also in granulosa cells, two major cell types in the ovary.

ORGANISM(S): Mus musculus

PROVIDER: GSE184636 | GEO | 2021/09/26

REPOSITORIES: GEO

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Reprogramming of ovarian aging epigenome by resveratrol [RNA-seq]

Project description:Depletion of oocytes and follicles and reduced oocyte quality contribute to age-associated ovarian senescence and infertility. Telomere shortening and altered methylation make two major contributions to general aging. Resveratrol acts as anti-oxidant and Sirt1 activator to alleviate aging including reproductive aging. It remains elusive whether resveratrol can reprogram the aging epigenome. We sought to examine aging ovarian epigenome and the potential effects of resveratrol by combined analysis of telomere length, transcriptome and methylome mainly in oocytes and also in granulosa cells, two major cell types in the ovary.

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Reprogramming of ovarian aging epigenome by resveratrol

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Resveratrol supplementation does not improve metabolic function in non-obese women with normal glucose tolerance

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The gene expression pattern of mice fed the resveratrol-enriched rice DJ526 was very different from mice fed either resveratrol or Dongjin rice alone

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Resveratrol supplementation does not improve metabolic function in non-obese women with normal glucose tolerance

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Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans

2011-11-08 | E-GEOD-32357 | biostudies-arrayexpress

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