Androgen receptor signalling driving cancer stem cells (CSCs) state in triple-negative breast cancer

ABSTRACT: Therapeutic strategies that improve survival outcomes for advanced-stage breast cancers have proven a major clinical challenge. Here, we define an androgen receptor signalling network that governs the maintenance and de novo formation of cancer stem cells in triple-negative breast cancer. In response to chemotherapy, androgen receptor activation switches cells into a cancer stem cell state, while androgen receptor antagonism suppresses cancer stem cell formation and function. In vivo, we validate that the androgen receptor antagonist, seviteronel, significantly improves chemotherapy-mediated inhibition of primary and metastatic tumour growth.

ORGANISM(S): Homo sapiens

PROVIDER: GSE184647 | GEO | 2023/12/03

REPOSITORIES: GEO