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RNA-seq analysis in uveal melanoma cells 92.1 and OMM1

ABSTRACT: The goals of this study are to compare gene expression profiles between uveal melanoma cells treated with either a scrambled antisense oligonucleotide (NTC) or a SAMMSON inhibiting ASO wether or not in combination with mTOR inhibitor GDC-0349. GDC-0349 synergizes with SAMMSON ASO to further reduce cell viability. Based on the RNA seq data, we observed only a limited number of DEGs in the GDC-0349 treated cells, while the number of DEGs in the combination significantly increased compared to SAMMSON ASO alone with many overlapping genes showing a more pronounced log2foldchange.

ORGANISM(S): Homo sapiens

PROVIDER: GSE184685 | GEO | 2022/09/24

REPOSITORIES: GEO

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