The dynamic rRNA ribomethylome drives stemness in acute myeloid leukemia [mRNA_FBL_KD]

ABSTRACT: Eukaryotic ribosomal RNA carries diverse posttranscriptional modifications, the function of which are mostly unexplored. The evolutionarily conserved 2’-O-methylation (2’-O-Me) occurs at more than 100 sites and is essential for ribosome biogenesis. Plasticity of 2´-O-Me in ribosomes and its functional consequences in human disease remain to be elucidated. The effect of rRNA 2’-O-Me on protein translation was investigated by nascent proteomcis analysis coupled with RNA-Seq in human leukemia cell line Kasumi-1 with and without knockdown of 2´-O-methyltransferase FBL.

ORGANISM(S): Homo sapiens

PROVIDER: GSE184721 | GEO | 2022/11/23

REPOSITORIES: GEO