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Transcriptomic data of liver endothelial cells from Alk1-(alias Acvrl1) knockout mice

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE184748 | GEO | 2023/04/06

REPOSITORIES: GEO

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Transcriptomic data of liver endothelial cells from Alk1-(alias Acvrl1) knockout mice II

Project description:Hereditary hemorrhagic telangiectasia (HHT, alias Rendu-Osler-Weber syndrome) is an autosomal dominant genetic disease that causes vascular malformations in multiple organs. Malformations and shunts in the liver are relevant for the long-term prognosis as they can lead to heart failure. Moreover, the role of ALK-1 in the hepatic vascular niche remains elusive. In this project, we aimed to establish a novel HHT model covering hepatic involvement by the disease and to investigate the role of ALK-1 in the hepatic vascular niche. We crossed Stab2-icre mice (MGI: 6741034) with Acvrl1-floxed mice (MGI: 4398901) to generate constitutive hepatic endothelial Acvrl1 knockout (Acvrl1-HEC-KO, alias Alk1-HEC-KO) mice. To dissect microvascular transcriptomic alterations, we performed RNA sequencing of freshly isolated hepatic endothelial cells from 3 months old mice. Transcriptomic analyses revealed an arterialization of hepatic vessels accompanied by loss of LYVE-1 and induction of Endomucin. The loss of endothelial Wnt2, Wnt9b, and Rspo3 led to a disruption of hepatic metabolic zonation with a dominance of periportal genes in Alk1-HEC-KO mice and HHT patients. Furthermore, we identified PRND (alias Doppel) and placenta growth factor (PlGF) as novel candidates of HHT pathogenesis in mice. ALK-1 controls hepatic metabolic zonation via Wnt signaling and suppresses PRND and PlGF that represent novel candidates in HHT pathogenesis.

2023-04-06 | GSE184747 | GEO

Transcriptomic data of whole liver from Alk1-(alias Acvrl1) knockout mice I

Project description:Hereditary hemorrhagic telangiectasia (HHT, alias Rendu-Osler-Weber syndrome) is an autosomal dominant genetic disease that causes vascular malformations in multiple organs. Malformations and shunts in the liver are relevant for the long-term prognosis as they can lead to heart failure. Moreover, the role of ALK-1 in the hepatic vascular niche remains elusive. In this project, we aimed to establish a novel HHT model covering hepatic involvement by the disease and to investigate the role of ALK-1 in the hepatic vascular niche. We crossed Stab2-icre mice (MGI: 6741034) with Acvrl1-floxed mice (MGI: 4398901) to generate constitutive hepatic endothelial Acvrl1 knockout (Acvrl1-HEC-KO, alias Alk1-HEC-KO) mice. To dissect hepatic transcriptomic alterations, we performed RNA sequencing of freshly isolated whole liver cells from 3 months old mice. Transcriptomic analyses revealed an arterialization of hepatic vessels accompanied by loss of LYVE-1 and induction of Endomucin. The loss of endothelial Wnt2, Wnt9b, and Rspo3 led to a disruption of hepatic metabolic zonation with a dominance of periportal genes in Alk1-HEC-KO mice and HHT patients. Furthermore, we identified PRND (alias Doppel) and placenta growth factor (PlGF) as novel candidates of HHT pathogenesis in mice. ALK-1 controls hepatic metabolic zonation via Wnt signaling and suppresses PRND and PlGF that represent novel candidates in HHT pathogenesis.

2023-04-06 | GSE184746 | GEO

DNMT1 KNOCKOUT IN MURINE LIVER

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-04-01 | E-GEOD-67771 | biostudies-arrayexpress

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2020-04-01 | GSE120283 | GEO

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2019-09-06 | GSE136912 | GEO

Knockout of Pseudouridine synthase 1 (PUS1) in mice.

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-05-16 | E-GEOD-77823 | biostudies-arrayexpress

Global transcript analysis of livers and/or jejunums of liver-specific Lrh-1 knockout as well as Lrh-1 K289R knockin mice

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-07-11 | E-GEOD-59333 | biostudies-arrayexpress

Gene expression data from kidney and liver of systemic Iah1-knockout mouse

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-05-01 | GSE93689 | GEO

Profiling of epigenetic and transcriptomic landscapes in normal mouse liver, phenobarbital exposed mouse livers and mouse liver tumours

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-05-17 | E-GEOD-77731 | biostudies-arrayexpress

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