Genomics

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Identification of primate renal salt-responsive gene networks that differ by blood pressure phenotype


ABSTRACT: Sodium-lithium countertransport activity (SLC) is an intermediate phenotype for salt sensitive hypertension; elevated SLC corresponds to increased risk of hypertension. Genetic epidemiology studies indicate that SLC is heritable in humans and nonhuman primates; however, little is known about genetic determinants explaining variation in SLC. In this study we identified dietary salt-responsive gene networks in baboon kidneys and salt-responsive networks that differ between baboons with normal and high blood pressure phenotypes.

ORGANISM(S): Papio hamadryas Homo sapiens

PROVIDER: GSE18484 | GEO | 2018/12/31

REPOSITORIES: GEO

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