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Single-Cell Transcriptomics of Human Substantia Nigra in Parkinson's Disease

ABSTRACT: Parkinson’s disease (PD) is the most common neurodegenerative movement disorder with unknown etiology. Loss of neuromelanin-containing dopaminergic (DA) neurons in the substanstia nigra (SN) is the hallmark of PD neuropathology. Here we performed single-nucleus RNA sequencing (snRNA-seq) of nuclei from the postmortem SN of control and idiopathic PD patients across various disease stages. The resulting transcriptomic atlas revealed a landscape of cellular alterations associated with disease progression in PD.

ORGANISM(S): Homo sapiens

PROVIDER: GSE184950 | GEO | 2022/03/28

REPOSITORIES: GEO

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