APOE4 cell-specific mechanisms underlying cerebrovascular disorder precede neuronal and synaptic dysfunction and cognitive deficits in mice

ABSTRACT: We performed single-nucleus RNA-sequencing of the cortex of APOE3 and APOE4 knock-in (KI)flox/flox mice to investigate the effects of human APOE4 gene on cell-specific signaling mechanisms at the BBB and in the brain.

ORGANISM(S): Mus musculus

PROVIDER: GSE185063 | GEO | 2022/08/22

REPOSITORIES: GEO