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Meso-Seq for in-depth transcriptomics in ultra-low amounts of FACS-purified neuronal nuclei

ABSTRACT: Profiling of gene expression in sparse populations of genetically defined neurons is essential for dissecting the molecular mechanisms that control the development and plasticity of neural circuits. However, current transcriptomic approaches are ill suited for detailed mechanistic studies in sparse neuronal populations, as they either are technically complex and relatively expensive (e.g., single-cell RNA sequencing [RNA-seq]) or require large amounts of input material (e.g., traditional bulk RNA-seq).

ORGANISM(S): Mus musculus Macaca fascicularis

PROVIDER: GSE185221 | GEO | 2022/08/11

REPOSITORIES: GEO

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