Targeting androgen receptor phase separation to overcome antiandrogen resistance mediated by "pharmacological condensates"

ABSTRACT: Analyze the transcriptomic changes of LNCaP upon DMSO, DHT, Enzalutamide(ENZ), ET516 treatment. The DHT treatment induced robust androgen receptor (AR) signaling up-regulation, wheras ENZ and ET516 can significantly restore DHT-induced AR signaling changes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE185223 | GEO | 2021/10/05

REPOSITORIES: GEO