Angiopoietin-Tie2 signaling protects the kidney from ischemia-reperfusion injury in mice

ABSTRACT: Single cell RNAseq analysis of kidneys from Hepta-ANG1-treated and vehicle-treated mice identified endothelial-specific gene signatures and emergence of a new glomerular endothelial subpopulation associated with improved kidney function. Total RNA of whole kidneys was sequenced to compare the transcriptional response of control and VE-PTPiKO kidneys after 5 hours of reperfusion. We saw fewer genes altered in the VE-PTPiKO kidney after IR injury compared to control.

ORGANISM(S): Mus musculus

PROVIDER: GSE185383 | GEO | 2023/01/23

REPOSITORIES: GEO