Single cell RNAseq data from Dlk1+ and Dlk1- aged murine hematopoietic stem cells

ABSTRACT: Quantification of gene expression noise on young versus aged bone marrow HSCs at single-cell resolution revealed Dlk1 increases both noise and expression levels upon aging. Dlk1, encoding a cell surface non-canonical Notch ligand, is partially expressed in the LT-HSC compartment, without generating clusters of individual subpopulations by conventional clustering analysis. We aimed to characterize the trascriptome of aged LT-HSC with positive and negative expression of Dlk1 cells. Dataset created as part of the publication: "VarID2 quantifies gene expression noise dynamics and unveils functional heterogeneity of ageing hematopoietic stem cells"

ORGANISM(S): Mus musculus

PROVIDER: GSE185637 | GEO | 2023/05/13

REPOSITORIES: GEO