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Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos

ABSTRACT: We report that oxidized nicotinamide adenine dinucleotide (NAD+) is indispensable for mouse pre-implantation development. NAD+ could avoids excessive minor zygotic gene activation (ZGA) by cooperating with SIRT1 to remove zygotic H3K27ac. In human, NAD+ supplement can promote the removal of zygotic H3K27ac and benefit pre-implantation development. Our findings demonstrate that precise and timely regulation of minor ZGA is controlled by metabolic dynamics, and enhance our understanding of the metabolism of mammalian early embryos.

ORGANISM(S): Mus musculus

PROVIDER: GSE185653 | GEO | 2022/10/05

REPOSITORIES: GEO

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