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Single-cell RNA/ATAC multiomic analysis of bone marrow stromal cells of young bones [Prrx1cre_P21_multiome]

ABSTRACT: A single nucleus transcriptomic and epigenomic profile of bone marrow stromal cells of the murine femur marked by Prrx1-cre at postnatal day 21 (P21)

ORGANISM(S): Mus musculus

PROVIDER: GSE185789 | GEO | 2021/10/16

REPOSITORIES: GEO

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Single-cell RNAseq analysis of bone marrow stromal cells of young bones [Prrx1cre_P21_RNA]

Project description:A single cell transcriptomic profile of bone marrow stromal cells of the murine femur marked by Prrx1-cre at postnatal day 21 (P21)

2021-10-16 | GSE185785 | GEO

Single-cell ATACseq analysis of bone marrow stromal cells of young bones [Prrx1cre_P21_ATAC]

Project description:A single cell chromatin accessibility profile of bone marrow stromal cells of the murine femur marked by Prrx1-cre at postnatal day 21 (P21)

2021-10-16 | GSE185791 | GEO

Single-cell RNAseq analysis of Fgfr3-creER-marked bone marrow stromal cells in young bones [Fgfr3CE;R26RtdT]

Project description:A single cell transcriptomic profile of Fgfr3-creER-marked bone marrow stromal cells of the murine femur at postnatal day 23 (P23), pulsed at P21.

2021-10-16 | GSE185792 | GEO

Single-cell RNAseq analysis of Gas1-creER-marked bone marrow stromal cells in young bones [Gas1CE;R26RtdT]

Project description:A single cell transcriptomic profile of Gas1-creER-marked bone marrow stromal cells of the murine femur at postnatal day 23 (P23), pulsed at P21.

2021-10-16 | GSE185790 | GEO

Single-cell RNAseq analysis of bone marrow stromal cells of old bones [Prrx1cre_18M_RNA]

Project description:A single cell transcriptomic profile of bone marrow stromal cells of the murine femur marked by Prrx1-cre at 18 months of age (18M)

2021-10-16 | GSE185786 | GEO

Single-cell RNAseq analysis of Fgfr3+ cell-derived bone marrow stromal cells, p53 Control [Fgfr3CE_p53-cHet]

Project description:A single cell transcriptomic profile of bone marrow stromal cells of the murine femur at 4 months of age (4M), lineage-marked by Fgfr3-creER at postnatal day 21 (P21), Control

2021-10-16 | GSE185787 | GEO

Single-cell RNAseq analysis of p53-deficient Fgfr3+ cell-derived bone marrow stromal cells [Fgfr3CE_p53-cKO]

Project description:A single cell transcriptomic profile of p53-deficient bone marrow stromal cells of the murine femur at 4 months of age (4M), lineage-marked by Fgfr3-creER at postnatal day 21 (P21)

2021-10-16 | GSE185788 | GEO

Single-cell RNA/ATAC multiomic analysis of bone marrow stromal cells of young bones [Prrx1cre_P21_multiome]

Project description:Single-cell RNA/ATAC multiomic analysis of bone marrow stromal cells of young bones [Prrx1cre_P21_multiome]

| PRJNA770755 | ENA

Next generation sequencing to do comparative transcriptome profiling of long bones from young and old mice

Project description:The goal of this study is to do a global transcriptiome profiling by NGS (RNA-seq) of RNA from long bone (Femur) of young (2 months) and aged (22 months) mice to understand how the bone function and their regulations are different between these two groups. Since loss of bone is prevalent with aging, we tried to find out what all genes related to bone function are affected at the expression level with aging. Using this gene expression data, we further tried to establish a relation between the pathways and regulators that contribute to this loss of function with biological replicates.

2023-12-15 | GSE220679 | GEO

Gene Expression Profiles of Jaw and Alveolar Bones Are Uniquely Different from Those of Trunk and Limb Bones

Project description:Certain bone graft materials are employed for alveolar bone regeneration, and autografts are commonly used. Alveolar and jaw bones are developmentally derived from neural crest cells, while most trunk and limb bones are derived from mesodermal mesenchymal cells. Consequently, the chosen bone graft material is likely to have a different developmental origin than the recipient bone. We hypothesized that there are differences in the gene expression profiles and bone healing capacities between bones with different developmental origins. Therefore, we investigated these properties in the maxilla, mandible, ilium and femur. DNA microarray data revealed close homology between the gene expression profiles of the ilium and femur. The gene expressions of Wnt-1, P75, SOX10, Nestin and Musashi-1 were significantly higher in the maxilla and mandible than in the ilium and femur. The frontal bone healed faster than the parietal bone. Parietal bone defects transplanted with maxillary and mandibular bone grafts exhibited closure. Thus, it is suggested that the maxilla and mandible have different gene expression profiles from the other bones examined, and exhibit neural crest cell properties with a marked healing ability in adults. The data further suggest that jaw bones are effective as both bone graft materials and graft beds.

2011-06-30 | GSE30167 | GEO

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