Pseudomonas aeruginosa gene regulation by Staphylococcus aureus exoproducts

ABSTRACT: Pseudomonas aeruginosa and Staphylococcus aureus are often co-isolated in persistent infections. The goal of this study was to determine how secreted products from S. aureus affect gene expression in P. aeruginosa. Therefore, media control or S. aureus supernatant was added to P. aeruginosa cultures at 25% total volume and gene expression was measured at 20 min, 1 h, and 2 h using RNA-seq. Overall, after addition of S. aureus supernatant, there was an upregulation in genes involved in metal deprivation and intermediate metabolite uptake.

ORGANISM(S): Pseudomonas aeruginosa

PROVIDER: GSE185963 | GEO | 2022/05/18

REPOSITORIES: GEO