Transcriptomics profile of mouse dendritic cell subsets during epicutaneous allergen immunotherapy (EPIT)

ABSTRACT: Epicutaneous immunotherapy (EPIT) protocols have recently been developed to restore tolerance in patients with food allergy (FA). The mechanisms by which EPIT protocols promote desensitization rely on a profound immune deviation of pathogenic T and B cell responses. To date, little is known about the contribution of skin dendritic cells (skDCs) to T cell remodelling and EPIT efficacy. Our results emphasize that the acquisition of distinct phenotypic and functional specializations by skDCs during EPIT is at the cornerstone of the desensitization process.

ORGANISM(S): Mus musculus

PROVIDER: GSE186052 | GEO | 2022/07/17

REPOSITORIES: GEO