Transcriptomics

Dataset Information

0

Therapeutic Effect of Histone Acetyltransferase Inhibitors on Galactose-Induced Cataract in Rats


ABSTRACT: We investigated the therapeutic effects of histone acetyltransferase (HAT) inhibitors on cataracts using an ex vivo model of galactose-induced cataracts in the rat lens.Among the tested HAT inhibitors, TH1834 was the only inhibitor that could completely reverse white opacities once formed in the lens. Combination treatment with C646/CPTH2 and CBP30/CPTH2 also had therapeutic effects. To identify the genes regulated by HAT inhibitors, we conducted microarray analysis of treated and untreated cataract samples.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE186248 | GEO | 2022/12/11

REPOSITORIES: GEO

Similar Datasets

2022-09-24 | GSE194074 | GEO
2023-11-18 | GSE223322 | GEO
2021-12-23 | GSE185143 | GEO
2024-02-16 | GSE240617 | GEO
2015-05-01 | E-GEOD-65500 | biostudies-arrayexpress
2021-03-10 | GSE157061 | GEO
2013-08-01 | E-GEOD-45981 | biostudies-arrayexpress
2022-08-15 | GSE211053 | GEO
2022-08-15 | GSE211052 | GEO
2022-08-15 | GSE211050 | GEO