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BCR-Seq of Germinal Center B cells from mice infected with LCMV

ABSTRACT: To study how acute or chronic viral infection (LCMV-WE or Docile) affect somatic hypermutation and/or affinity maturation of Germinal Center B cells, wild-type or Bmi1-deleted mice were infected with either the acute (WE) versus chronic (Docile) strains of LCMV, GC B cells (CD19+IgDloCD95+CD38loCD138-) were isolated 14 days post-infection and thei BCR was sequenced.

ORGANISM(S): Mus musculus

PROVIDER: GSE186274 | GEO | 2021/10/20

REPOSITORIES: GEO

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Gene expression profiles in GC B cells of wild-type and Bmi1 cKO mice during acute or chronic viral infection

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