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An uncharacterized gene, C7orf26, identified from an autosomal dominant ocular disease functions in mRNA splicing

ABSTRACT: An uncharacterized gene, C7orf26 was expected to function with the integrator complex in mRNA splicing. To address the involvement of mRNA splicing, we performed microarray analysis of HeLa/C7orf26 siRNA cells and HeLa/non-specific (NS) and identified 700 transcripts that were downregulated by 50% or more in C7orf26 siRNA-treated HeLa cells. Gene set enrichment analysis showed that genes tagged with ‘alternative splicing’ or ‘splice variant’ occupy a large fraction of the downregulated genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE186323 | GEO | 2023/03/08

REPOSITORIES: GEO

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