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Human microRNA-122b-5p regulates chikungunya virus replication in macrophages by directly targeting viral 3'-UTR and cellular histone deacetylase 4

ABSTRACT: We found that Histone Deacetylase 4 is the target of human miR-122b-5p using transcriptome approach and report thst HDAC4 is downregulated in CHIKV infected human macrophages through global transcriptome profiling

ORGANISM(S): Homo sapiens

PROVIDER: GSE186564 | GEO | 2024/10/31

REPOSITORIES: GEO

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Human microRNA-122b-5p regulates chikungunya virus replication in macrophages by directly targeting viral 3'-UTR and cellular histone deacetylase 4

Project description:Human microRNA-122b-5p regulates chikungunya virus replication in macrophages by directly targeting viral 3'-UTR and cellular histone deacetylase 4

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microRNA expression profile in HEK293T cells infected with Chikungunya virus

Project description:HEK293T grown in 6 well plates were infected with CHIKV and total RNA was isolated from cells at 0, 12 and 24 hrs post infection. CHIKV microRNA expression signature was generated. Cells grown on 6-well plates. Three biological replicates of uninfected and two biological replicates of infected samples

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Project description:Human monocyte-derived macrophage cells were infected with Chikungunya virus (CHIKV) to identify and quantify intracellular transcriptional changes that contribute to the host response to infection with CHIKV. RNA was collected from these cells at 8 and 24 hours post-infection (hpi) and were compared to mock-infected cells. The RNAseq data was then analyzed to determine the genes, functions, and signaling pathways that were significantly affected in an effort to predict existing drugs that could be repurposed as potential therapeutics for CHIKV.

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Gene expression profile in HEK293T cells infected with Chikungunya virus

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