Inherited blood cancer predisposition through altered transcription elongation [Pro-seq]

ABSTRACT: We identified CTR9 mutants as rare heritible contributing factors to several blood cancers. We later identified partial loss of CTR9 is capable of driving key hematopoietic maintenance and self-renewal gene expression through altered transcription elongation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE186588 | GEO | 2024/01/13

REPOSITORIES: GEO