Differentiation of NUT midline carcinoma by epigenomic reprogramming

ABSTRACT: Knockdown of the oncogene, BRD4-NUT, in a rare cancer, termed NUTmidline carcinoma (NMC), results in morphologic features consistent with squamous differentiation. Treatment with the HDAC-inhibitor, TSA, appears to cause the same phenotype. Here, we use gene expression profiling to compare the changes in gene expression following BRD4-NUT knockdown and TSA treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE18668 | GEO | 2011/07/01

SECONDARY ACCESSION(S): PRJNA121537

REPOSITORIES: GEO