The effects of Hmgb1 depletion on gene expression in human cells

ABSTRACT: High Mobility Group Box 1 (HMGB1) is a highly abundant and evolutionarily conserved non-histone chromatin component with the ability to bind and bend DNA. The protein is involved in fundamental nuclear processes including nucleosome sliding, transcription, replication, V(D)J recombination and DNA transposition. To assess the functional impact of HMGB1 on transcription we performed gene expression profile analyses of HeLa cells stably transfected with an anti-HMGB1 shRNA expressing plasmid or a control plasmid.

ORGANISM(S): Homo sapiens

PROVIDER: GSE18721 | GEO | 2011/06/28

SECONDARY ACCESSION(S): PRJNA121677

REPOSITORIES: GEO