Three-dimensional tissue-engineered human skeletal muscle model of satellite cell quiescence

ABSTRACT: In vivo, satellite cells (SCs) are essential for skeletal muscle repair. However, in vitro investigation of SC function is challenged by isolation-induced SC activation, loss of the native quiescent state, and differentiation to myoblasts. This study applies tissue-engineered human skeletal muscle to track myoblast deactivation to 3D-SCs, which bear a quiescent phenotype, as well as examine melittin-induced injury response.

ORGANISM(S): Homo sapiens

PROVIDER: GSE188215 | GEO | 2021/11/11

REPOSITORIES: GEO