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Comparative Analysis of Gene expression profile in the Adipose Tissue of Obese Adult Mice with Rapid Infantile Growth after Undernourishment in utero

ABSTRACT: Rapid growth in infancy considerably increases the risk of obesity and metabolic disorders in adulthood especially among neonates born small. To investigate the molecular mechanism of rapid infantile growth (RG) following undernourishment in utero (UN) in the deterioration of the adult fat deposit, we developed a mouse animal UN model by maternal energy restriction, followed by RG by adjustment of 4 pups per litter soon after birth. High fat diet (FHD) was supplied to the weaned pups, with or without the treatment of tauroursodeoxycholic acid (TUDCA; TU). UN-RG pups showed deterioration of diet-induced obesity and fat deposit, which was ameliorated by TU. We carried out microarray analysis of epidydimal adipose tissue.

ORGANISM(S): Mus musculus

PROVIDER: GSE188306 | GEO | 2021/11/06

REPOSITORIES: GEO

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