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Gene expression profiling upon treatment with NTX-301

ABSTRACT: A novel hypomethylating agent NTX-301 is a promising therapeutic agent for AML patients. To examine its mechanisms of action, we produced gene expression data upon treatment with NTX-301 or decitabine (DAC) in AML cell lines.

ORGANISM(S): Homo sapiens

PROVIDER: GSE188392 | GEO | 2022/04/20

REPOSITORIES: GEO

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Gene expression profiling upon treatment with NTX-301 in MV4-11

Project description:A novel hypomethylating agent NTX-301 is a promising therapeutic agent for AML patients. To examine its mechanisms of action, we produced gene expression data upon treatment with NTX-301 or decitabine (DAC) in MV4-11 cell line.

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DNA methylation profiling upon treatment with NTX-301 or decitabine in AML cells

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Project description:Acute myeloid leukemia (AML), and other myeloid malignancies, are frequently treated with hypomethylating agents like decitabine. Alterations in the epigenome, induced by decitabine, are likely to result in gene expression changes. The effects of decitabine have not been systemically studied using primary AML samples. We cultured 18 different primary AML samples for 7 days, the last 3 days of which included 100 nM decitabine (DAC) or 100 nm cytarabine (AraC). We hypothesized that decitabine treatment would result in detectable and consistent gene expression changes. For comparison, we also analyzed mRNA from cells treated with DMSO control (mock) and mRNA from uncultured cells taken at the time of diagnosis.

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Gene expression profiling upon treatment with NTX-301

Project description:Gene expression profiling upon treatment with NTX-301

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Project description:Gene expression profiling upon treatment with NTX-301 in MV4-11

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DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8

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