Isoginkgetin induces autophagic cell death in hepatocellular carcinoma [ChIP-Seq]

ABSTRACT: Purpose: Our previous studies have identified isoginkgetin as an inducer of autophagic cell death in hepatocellular carcinoma. We set out to analyze how isoginkgetin regulates the genome-wide enhancer activity in HepG2 cells. Methods: ChIP-seq for H3K27ac was performed in HepG2 followed by treatment with 20 μM isoginkgetin for 24 h. Conclusions: Isoginkgetin treatment reduces the expression of glucose transporters and inhibts SLC2A1 enhancer activity in HepG2 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE188534 | GEO | 2023/03/22

REPOSITORIES: GEO