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PHOX2B promotes the occurrence and development of neuroblastoma by activating the MAPK signaling pathway

ABSTRACT: Studies have shown that PHOX2B is the first predisposition gene identified in neuroblastoma.To explore PHOX2B-dependent gene regulation, RNA-seq analysis was performed. Compared with the control group, PHOX2B knockdown SK-N-BE(2) cells showed differently expressed genes. We found that PHOX2B activates the MAPK signaling pathway to promote the occurrence and development of neuroblastoma.

ORGANISM(S): Homo sapiens

PROVIDER: GSE188622 | GEO | 2022/08/29

REPOSITORIES: GEO

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