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Sex and mutation specific p53 gain-of-function activity in gliomagenesis [ChIP-seq]

ABSTRACT: ChIP-seq analysis of Primary cortical astrocytes harboring a single floxed Trp53 allele harvested from male and female postnatal day one pups, and transduced with mutant p53;IRES GFP followed by CRE recombinase. p53 protein was immunoprecipated from fixed whole chromatin from cells expressing one of three mutants or p53 KO control.

ORGANISM(S): Mus musculus

PROVIDER: GSE188708 | GEO | 2021/11/16

REPOSITORIES: GEO

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Sex and mutation specific p53 gain-of-function activity in gliomagenesis [RNA-seq]

Project description:The goal of this study is to compare the sex specific effects of the expression of p53 missense mutations on the transcriptomes of male and female primary astrocytes. Primary cortical astrocytes harboring a single floxed Trp53 allele were harvested from male and female postnatal day one pups, and transduced with mutant p53;IRES GFP followed by CRE recombinase. mRNA was collected from male and female astrocytes transduce with mouse Trp53:R172H, Trp53:Y202C, or Trp53:Y217C. This study revealed sex specific gain-of-function effects on the transcriptomes of each cell line that correlated with cancer pathways.

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Sex and mutation specific p53 gain-of-function activity in gliomagenesis

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Sex and mutation specific p53 gain-of-function activity in gliomagenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-11-16 | GSE188710 | GEO

Sex and mutation specific p53 gain-of-function activity in gliomagenesis [RNA-seq]

Project description:Sex and mutation specific p53 gain-of-function activity in gliomagenesis [RNA-seq]

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Sex and mutation specific p53 gain-of-function activity in gliomagenesis [ChIP-seq]

Project description:Sex and mutation specific p53 gain-of-function activity in gliomagenesis [ChIP-seq]

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Genome-wide transcriptome analyses of transgenic mice, that express Cre recombinase flanked by mutated estrogen receptors (MerCreMer; mcm), and carry loxP-flanked sequences of p53 and Mdm2 was performed in the presence and absence of Tamoxifen

Project description:Genome-wide transcriptome analyses of transgenic mice, that express Cre recombinase flanked by mutated estrogen receptors (MerCreMer; mcm), and carry loxP-flanked sequences of p53 and Mdm2 was performed in the presence and absence of Tamoxifen.<br>The molecular mechanisms underlying heart failure remain poorly understood. As such, identifying the factors which effectively maintain cardiac tissue homeostasis is of great scientific and clinical importances. The tumor suppressor Trp53 (p53) inhibits cell growth after acute stress by regulating gene transcription. The mammalian genome contains hundreds of p53 binding sites. However, whether p53 participates in the regulation of cardiac tissue homeostasis under normal conditions is not known. To examine the physiologic consequences of p53 and Mdm2 ablation in adult cardiomyocytes in vivo, cardiac morphology and function were assessed in conditional mutant mice.

2017-02-23 | E-MTAB-5441 | biostudies-arrayexpress

Expression data from 9 and 13 weeks old TIFIAD1Cre mice

Project description:We have investigated the p53-dependent stress response in medium spiny neurons (MSNs) that degenerate in Huntington’s disease. To induce p53 signaling cascade, we have genetically inactivated by the Cre/loxP system the essential RNA polymerase I (Pol I) transcription factor TIF-IA, leading to stabilization of p53 and induction of p53-dependent apoptosis. In the present study, we selectively ablated the TIF-IA gene in MSNs by crossing TIF-IAflox/flox mice, homozygous for the floxed TIF-IA allele with transgenic mice expressing the Cre recombinase under the control of the D1 dopamine receptor (D1R) promoter.

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Affymetrix Mouse Diversity Genotyping Array Data for p53 deficient mice

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Affymetrix Mouse Diversity Genotyping Array Data for p53 deficient mice

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