Generation of human iPS cell-derived mesenchymal cells capable of forming alveolar organoids [scRNA-Seq]

ABSTRACT: We have developed a method to generate human induced pluripotent stem cell (iPSC)-derived mesenchymal cells (iMES) that were able to induce AT1 and AT2 epithelial cells within their organoids (iMES-AO). Single-cell transcriptome analysis comparing iMES-AO with our previously reported alveolar organoids using human fetal lung fibroblasts delineated not only differences in composition of epithelial lineages but also distinctive mesenchymal lineages.

ORGANISM(S): Homo sapiens

PROVIDER: GSE188823 | GEO | 2022/09/16

REPOSITORIES: GEO