RNA-sequencing of wild-type and ArhGEF1-deficient splenic cDC2s

ABSTRACT: We analyzed the transcriptome differences of wild-type and ArhGEF1-deficient (Arhgef1-/-) type-2 conventional dendritic cells (cDC2s) in spleen. Wild-type or ArhGEF1-deficient (Arhgef1-/-) bone marrow cells were transferred into lethal irradiated CD45.1 mice. 8 weeks later, splenic cDC2s were purified and prepared for RNA-seq analysis. The gene expression profiles of CD97-, Gα13- and ArhGEF1-deficient cDC2s were highly similar, providing evidence that these molecules function in the same pathway.

ORGANISM(S): Mus musculus

PROVIDER: GSE188833 | GEO | 2022/03/23

REPOSITORIES: GEO