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The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE188854 | GEO | 2022/06/03

REPOSITORIES: GEO

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The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells [RNA-seq]

Project description:T cell antigen receptor (TCR) signaling controls the development, activation and survival of T cells by involving several layers and numerous mechanisms of gene regulation. N6-methyladenosine (m6A) is the most prevalent mRNA modification affecting splicing, translation and stability of transcripts. Here, we describe the Wtap protein as essential for m6A methyltransferase complex function and reveal its crucial role in TCR signaling. Wtap and m6A methyltransferase functions were required for the differentiation of thymocytes, control of activation-induced death of peripheral T cells and prevention of colitis by enabling gut RORγt+ regulatory T cell function. Transcriptome and epitranscriptomic analyses reveal that m6A modification destabilizes Orai1 and Ripk1 mRNAs. Lack of post-transcriptional repression of the encoded proteins correlated with increased store-operated calcium entry (SOCE) activity and diminished survival of T cells. These findings uncover how m6A modification impacts on TCR signal transduction and determines activation and survival of T cells.

2022-06-03 | GSE188814 | GEO

The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells [YTHDF2-iCLIP]

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The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells [m6A-CLIP]

2022-06-03 | GSE188853 | GEO

The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells

Project description:The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells

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The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells [m6A-CLIP]

Project description:The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells [m6A-CLIP]

| PRJNA780524 | ENA

The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells [YTHDF2-iCLIP]

Project description:The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells [YTHDF2-iCLIP]

| PRJNA780503 | ENA

The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells [RNA-seq]

Project description:The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells [RNA-seq]

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