Transcriptomics

Dataset Information

0

Single-Cell Sequencing Reveals the Overall Changes in Tumor Microenvironment Mediated by CD39i


ABSTRACT: Here we identified the ecto-enzyme, CD39 (encoded by ENTPD1), as a potential therapeutic target for BC via single-cell transcriptome analysis of BC and para-cancer tissues. In a subcutaneous model, inhibition of CD39 (CD39i) is able to limit the growth of BC and improve overall survival of tumor-bearing mice. Via single-cell sequencing of tumor infiltrated immune cells, we found that CD39i with POM-1 increased the intratumor NK cells, conventional type 1 dendritic cells (cDC1) and CD8+ T cells, along with decreased Treg abundance. The anti-tumor effect and reprogram of tumor microenvironment are blockade in a cDC1-deficient Batf3−/− model.

ORGANISM(S): Mus musculus

PROVIDER: GSE189127 | GEO | 2022/09/06

REPOSITORIES: GEO

Similar Datasets

2023-10-24 | PXD039789 | Pride
2024-01-01 | GSE221881 | GEO
2021-02-24 | GSE149544 | GEO
2019-02-01 | GSE125965 | GEO
2020-09-29 | GSE136551 | GEO
2019-06-23 | GSE132768 | GEO
2022-06-21 | GSE168477 | GEO
2022-03-05 | GSE162650 | GEO
2024-01-23 | GSE249361 | GEO
2019-06-23 | GSE132770 | GEO