Multi-omics integration analysis identifies novel genes for alcoholism with potential link to neurodegenerative diseases

ABSTRACT: Alcohol use disorders (AUD) are complex, moderately heritable, psychiatric disorders associated with heightened morbidity and mortality. Genome-wide association studies of AUD and drinks per week (DPW) have identified multiple risk loci however few studies have examined the intersection between the loci and genes associated with AUD and DPW, especially with respect to their functional and regulatory significance. In this study we use a muti-omics systems approach to identify causal variants and genes associated with AUD and DPW.

ORGANISM(S): Homo sapiens

PROVIDER: GSE189139 | GEO | 2021/11/20

REPOSITORIES: GEO