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DNA methylation and transcriptomic signatures in patients with peanut- and multi-food allergy (RNA-Seq)

ABSTRACT: This study profiled the epigenomes and transcriptomes of total nCD4T cell populations from adolescents with peanut-only (single food allergy- SA) and multi-food allergy (MA) at quiescence and following activation with anti-CD3/antiCD28

ORGANISM(S): Homo sapiens

PROVIDER: GSE189149 | GEO | 2022/02/28

REPOSITORIES: GEO

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DNA methylation and transcriptomic signatures in patients with peanut- and multi-food allergy (Methylation)

Project description:This study profiled the epigenomes and transcriptomes of total nCD4T cell populations from adolescents with peanut-only (single food allergy- SA) and multi-food allergy (MA) at quiescence and following activation with anti-CD3/antiCD28

2022-02-28 | GSE189148 | GEO

DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy [RNA-Seq]

Project description:This study profiled the epigenomes and transcriptomes of total B cell populations from adolescents with peanut-only (single food allergy- SA) and multi-food allergy (MA).

2021-09-01 | GSE165316 | GEO

DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy [array]

Project description:This study profiled the epigenomes and transcriptomes of total B cell populations from adolescents with peanut-only (single food allergy- SA) and multi-food allergy (MA). We found distinct epigenetic and transcriptomic differences between food allergic patients and controls, in addition to SA- and MA- group specific signatures, with

2021-09-01 | GSE166067 | GEO

Ar101 Oral Desensitization Therapy for Peanut Allergy Induces Dynamic Changes in Peanut-Specific Immune Responses

Project description:Peanut allergy is increasingly prevalent among children in the United States and other industrialized countries and is now estimated to affect approximately 2% of children. While there are currently no approved treatment options, peanut allergy usually persists into adulthood, can be life-threatening, and accounts for most deaths related to food allergy. Here, we track peanut-reactive CD4+ T effector (pTeff) cells using the CD154 up-regulation assay. We found that CRTH2+ pTeff cells and CCR6+ pTeff cells represent two mutually exclusive, non-overlapping cellular and molecular entities involved in food allergic diseases.

2022-08-10 | GSE196495 | GEO

CD23+IgG1+ memory B cells are poised to switch to pathogenic IgE production in food allergy

Project description:Food allergy is caused by allergen-specific IgE but little is known about the B cell memory of persistent responses. Here we describe in pediatric peanut allergy a population of CD23+IgG1 memory B cells that contains peanut-specific clones and generates IgE plasma cells on activation. Through single cell transcriptomics and B cell receptor (BCR) sequencing, we characterized FCER2/CD23+ IgG1 memory B cells co-expressing IL4R, IL13RA1, IGHE and carrying highly mutated BCRs. Further we found that peanut allergen (Ara h 2)-specific B cells were mostly IgG1 memory cells, carried highly mutated BCRs compared to diphtheria toxin-specific B cells, and expressed FCER2 and germlin IGHE. Our findings suggest that CD23+IgG1+ memory B cells transcribing IGHE are a unique memory population containing precursors for pathogenic IgE in food allergy.

2023-11-16 | GSE208235 | GEO

Blood DNA methylation biomarkers predict clinical reactivity in food-sensitized infants

2015-01-01 | GSE59999 | GEO

Gene expression data from human myeloid dendritic cells stimulated with peanut protein and other allergens

Project description:Peanut protein is a remarkably potent food allergen in susceptible individuals. The frequency of peanut allergy is approximately 1% in the US population. Peanut allergy often presents with severe symptoms, and it is seldom outgrown. We sought to understand how peanut protein activates human dendritic cells, which are crucial in promoting the activation and differentiation of pathogenic peanut-specific Th2 cells that drive allergic responses.

2020-10-21 | GSE159706 | GEO

Antibody repertoires in peanut allergy

Project description:Antibody repertoires in peanut allergy

| PRJNA378451 | ENA

Skin inflammation exacerbates food allergy symptoms in epicutaneously sensitized mice

Project description:Cutaneous exposure to food antigen through impaired skin barrier has been shown to induce epicutaneous sensitization, and thereby cause IgE-mediated food allergy. We examined whether skin barrier impairment deteriorated food allergy symptoms in epicutaneously sensitized mice. To clarify the association between skin inflammation and food allergy symptoms, we analyzed gene expression at skin lesions using a GeneChip.

2017-06-30 | GSE95278 | GEO

Prediction of clinical reactivity in food sensitized individuals from blood DNA methylation profiles

Project description:Genome wide DNA methylation profiling study of PBMC from 71 unique primary patient blood samples. The Illumina Human Methylation 450k array was used. 29 challenge proven food allergy, 29 sensitized but oral tolerant, 13 non food allergics Mixture of food allergy phenotypes (egg allergic (15), peanut allergic (14)), food sensitization phenotypes (egg sensitized (14), peanut sensitized (15)). 4 samples had technical replicate hybridzations. Bisulphite converted DNA from the 75 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip v1.2. Technical replicates were combined during processing, resulting in normalized Beta values for 71 unique primary patient blood samples.

2015-01-01 | E-GEOD-59999 | biostudies-arrayexpress

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