A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer

ABSTRACT: The PHIP chromatin reader protein is mutated in Chung-Jansen syndrome, a neurodevelopmental disorder with autism like symptoms. Here we have characterized the chromatin binding properties of PHIP using a variety of in vitro and in vivo methods.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE189235 | GEO | 2021/11/22

REPOSITORIES: GEO