A two-color haploid genetic screen identifies novel host factors involved in HIV-1 latency

ABSTRACT: To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latently HIV-1-infected pseudohaploid KBM7 cell line (Hap-Lat). Following mutagenesis, insertions were mapped to the genome, and bioinformatic analysis resulted in the identification of 69 candidate host genes involved in maintaining HIV-1 latency.

ORGANISM(S): Homo sapiens

PROVIDER: GSE189314 | GEO | 2021/11/22

REPOSITORIES: GEO