Deep mutational scan of a drug efflux pump reveals its structure-function landscape

ABSTRACT: Drug efflux is a common resistance mechanism found in bacteria and cancer cells. Although several structures of drug efflux pumps are available, they provide only limited functional information on the phenomenon of drug efflux. Here, we performed deep mutational scanning (DMS) on the bacterial ATP binding cassette (ABC) transporter EfrCD from Enterococcus faecalis to determine the drug efflux activity profile of more than 1400 single variants

ORGANISM(S): Enterococcus faecalis

PROVIDER: GSE189399 | GEO | 2021/11/25

REPOSITORIES: GEO