DNA methylation patterns in monocytes associate and evolve with prognosis in undifferentiated arthritis [MACs]

ABSTRACT: Ontogenic origin of monocytic cells in the synovial fluid is currently under discussion. Also, the polarization of these cells have been described to a play a role in the pathogenic joints of arthritis patients. To answer these questions, we analyzed data from blood and SF monocytes and compared them with those of in vitro-generated monocyte-derived macrophages. All conditions were compared, and differences were characterized, considering experimental condition (MO, M-CSF or GM-CSF), compartment (blood or SF) and patient prognosis (good or poor).

ORGANISM(S): Homo sapiens

PROVIDER: GSE189422 | GEO | 2022/05/25

REPOSITORIES: GEO