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The phosphate exporter XPR1/SLC53A1 is required for the tumorigenicity of ovarian cancer.

ABSTRACT: Ovarian cancer is the fifth cause of cancer-related death in women. Ovarian clear cell carcinoma (OCCC) is a chemotherapy-resistant epithelial ovarian cancer with poor prognosis. As a basis for the development of therapeutic agents that may improve the prognosis of OCCC, we performed a screen for proteins critical for the tumorigenicity of OCCC using the CRISPR/Cas9 system. Here we show that knockdown of the phosphate exporter XPR1/SLC53A1 induces the growth arrest and apoptosis of OCCC cells in vitro. Moreover, we demonstrate that knockdown of XPR1/SLC53A1 inhibits the proliferation of OCCC cells xenografted into immunocompromised mice. These results suggest that XPR1/SLC53A1 plays a critical role in the tumorigenesis of OCCC cells. We speculate that XPR1/SLC53A1 might be a promising molecular target for the therapeutic treatment of OCCC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE189552 | GEO | 2022/07/07

REPOSITORIES: GEO

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Expression data from ovarian cancer cell lines

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The phosphate exporter XPR1/SLC53A1 is required for the tumorigenicity of ovarian cancer.

Project description:The phosphate exporter XPR1/SLC53A1 is required for the tumorigenicity of ovarian cancer.

| PRJNA783541 | ENA

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